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The Times investigation, based on heaps of pages of exclusive Purdue documents and other records, observed that:
Purdue has known approximately the hassle for decades. Even before OxyContin went available on the market, scientific trials showed many sufferers weren’t getting 12 hours of remedy. Since the drug’s debut in 1996, the company has been faced with extra proof, along with court cases from docs, reviews from its personal income reps and unbiased research.
The corporation has held rapid to the declare of 12-hour alleviation, in part to defend its revenue. OxyContin’s market dominance and its excessive charge — as much as loads of greenbacks in keeping with bottle — hinge on its 12-hour duration. Without that, it offers little benefit over much less high priced painkillers.
When many docs started out prescribing OxyContin at shorter periods within the past due Nineties, Purdue executives mobilized loads of income reps to “refocus” physicians on 12-hour dosing. Anything shorter “needs to be nipped in the bud. NOW!!” one manager wrote to her body of workers.
Purdue tells docs to prescribe more potent doses, no longer more frequent ones, when sufferers whinge that OxyContin doesn’t closing 12 hours. That method creates dangers of its personal. Research suggests that the stronger the dose of an opioid consisting of OxyContin, the more the possibility of overdose and loss of life.
More than half of of lengthy-time period OxyContin users are on doses that public health officers bear in mind dangerously excessive, according to an evaluation of national prescription statistics performed for The Times.
Over the ultimate twenty years, extra than 7 million Americans have abused OxyContin, according to the federal authorities’s National Survey on Drug Use and Health. The drug is broadly blamed for putting off the state’s prescription opioid epidemic, which has claimed more than a hundred ninety,000 lives from overdoses regarding OxyContin and other painkillers because 1999.